Our briefing paper on Substance misuse – Drugs has been updated. Substance misuse is defined as regular excessive consumption of, and/or dependence on, psychoactive substances, leading to social, psychological, physical or legal problems. It includes problematic use of both legal and illegal drugs, and alcohol (although there is a separate briefing for alcohol). The paper investigates the extent of drug-related substance misuse in Norfolk as well as the health and wellbeing impact on the individuals.